Brominated 4-(trifluoromethyl)pyrimidines: A convenient access to versatile intermediates
2004
Abstract
An expedient route to all three monobrominated and all three dibrominated isomers of 4-(trifluoromethyl)pyrimidine, and to several other halogenated pyrimidines, is described. Key steps are the electrophilic introduction of the halogen in the 5-position of 2- or 4-pyrimidinones, the bromodeoxygenation of pyrimidinones or thiopyrimidinones using phosphorus tribromide, and the partial debromination of dibromo-4-(trifluoromethyl)pyrimidines. [on SciFinder (R)]
Details
Title
Brominated 4-(trifluoromethyl)pyrimidines: A convenient access to versatile intermediates
Author(s)
Ondi, Levente ; Lefebvre, Olivier ; Schlosser, Manfred
Published in
European Journal of Organic Chemistry
Issue
17
Pages
3714-3718
Date
2004
Keywords
Bromination; Deoxidation (bromodeoxygenation of pyrimidinones or thiopyrimidinones using phosphorus tribromide); Halogenation (of 4-(trifluoromethyl)pyrimidines); Debromination (partial debromination of dibromo-4-(trifluoromethyl)pyrimidines); brominated trifluoromethylpyrimidine prepn; pyrimidine trifluoromethyl bromo prepn
Note
CAN 141:395506 28-16 Heterocyclic Compounds (More Than One Hetero Atom) Institut de Chimie moleculaire et biologique,Ecole Polytechnique Federale,Lausanne,Switz. Journal 1434-193X written in English. 57-13-6 (Urea); 62-56-6 (Thiourea); 372-31-6 (Ethyl 4,4,4-trifluoroacetoacetate); 326894-81-9 Role: RCT (Reactant), RACT (Reactant or reagent) (prepn. of halogenated 4-(trifluoromethyl)pyrimidines); 368-54-7P; 672-45-7P; 1546-78-7P; 104048-92-2P; 126538-81-6P; 785777-90-4P; 785777-94-8P; 785777-95-9P; 785777-96-0P; 785777-97-1P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. of halogenated 4-(trifluoromethyl)pyrimidines); 785777-87-9P; 785777-88-0P; 785777-89-1P; 785777-91-5P; 785777-92-6P; 785777-93-7P; 785777-98-2P; 785777-99-3P; 785778-00-9P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of halogenated 4-(trifluoromethyl)pyrimidines)
Other identifier(s)
DAR: 5708
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Laboratories
LSCO
Record Appears in
Scientific production and competences > SB - School of Basic Sciences > SB Archives > LSCO - Laboratory of Organic Synthesis and Catalysis
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Record creation date
2006-03-03