The organometallic approach to molecular diversity - halogens as helpers
A review. Strategies to functionalize simple, though structurally challenging, compds. in regiodivergent manner are outlined. The starting materials are inexpensive (5-500 e/mol) arenes or heterocycles bearing heterosubstituents such as Cl, F, CF3, OCF3, and OMe. A metal is introduced at the targeted position either by direct hydrogen/metal exchange or, if this is not feasible, by use of organometallic precursor species as relay stations. The derivs. thus produced are versatile intermediates that may be employed as building blocks for further elaboration or even as scaffolds in combinatorial synthesis. [on SciFinder (R)]
2001
21
3975
3984
CAN 136:231907 21-0 General Organic Chemistry Section de Chimie de l'Universite (BCh),Lausanne-Dorigny,Switz. Journal; General Review 1434-193X written in English. 71-43-2DP (Benzene); 110-86-1DP (Pyridine); 288-13-1DP (Pyrazole) Role: SPN (Synthetic preparation), PREP (Preparation) (functionalization of arenes and heteroarenes by metalation)
REVIEWED