Infoscience

Journal article

8-Methoxyisoquinoline derivatives through ortho-selective metalation of 2-(3-methoxyphenyl)ethylamine

Butyllithium in Et2O smoothly metalates 3-MeOC6H4CH2CH2NHCOCMe3 at the ortho position flanked by the two substituents. Subsequent reaction with DMF followed by acid catalyzed cyclization and redn. gives 8-methoxy-1,2,3,4-tetrahydroisoquinoline (I). [on SciFinder (R)]

Fulltext

Related material