Infoscience

Journal article

Polyimide-polyethylene glycol block copolymers: synthesis, characterization, and initial evaluation as a biomaterial

Block copolyimides with varying amounts of polyethylene glycol (PEG) were synthesized and characterized by copolymerization of diaminodiphenyl ether (DDE), amino terminated PEG, and benzophenone tetracarboxylic acid dianhydride (BTDA). Strong materials were obtained, with enhanced flexibility as compared to the parent DDE-BTDA polyimide homopolymer. Incorporation of PEG led to an increase in water absorption by these copolymers, and hydrophilicity was increased as reflected by a decrease in air-water-polymer contact angle. These materials supported less cell adhesion in vitro than the parent polyimide homopolymer. Short term in vivo evaluation of these copolymers showed reduced fibrous encapsulation than was observed in the absence of PEG. [on SciFinder (R)]

    Reference

    • LMRP-ARTICLE-1994-007

    Record created on 2006-02-27, modified on 2016-08-08

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