000081193 001__ 81193
000081193 005__ 20180317094223.0
000081193 037__ $$aCONF
000081193 245__ $$aDelivery of antisense oligonucleotides from photopolymerized hydrogels
000081193 269__ $$a1993
000081193 260__ $$c1993
000081193 336__ $$aConference Papers
000081193 520__ $$aAntisense oligonucleotides promise to be highly potent therapeutic agents. Nanomolar extracellular concns. of phosphorothioate oligonucleotides have been reported to significantly alter gene expression in cultured cells. (Tidd, 1990). PEG derived hydrogels appear to be appropriate for delivering these concns. or higher for prolonged periods of time, and should protect the antisense oligonucleotides from enzymic degrdn. prior to cellular uptake. Release from these hydrogels follows predictable and alterable kinetics. The addnl. ability to polymerize the oligonucleotide-contg. macromer soln. in situ makes this advancement particularly exciting. [on SciFinder (R)]
000081193 700__ $$aHill-West, J. L.
000081193 700__ $$0240350$$aHubbell, J. A.$$g141360
000081193 773__ $$q248-9$$tProc. Int. Symp. Controlled Release Bioact. Mater., 20th
000081193 909CO $$ooai:infoscience.tind.io:81193$$pconf
000081193 909C0 $$0252196$$pLMRP$$xU11032
000081193 937__ $$aLMRP-CONF-1993-003
000081193 970__ $$a7/LMRP
000081193 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000081193 980__ $$aCONF