000081101 001__ 81101
000081101 005__ 20180317093558.0
000081101 0247_ $$2doi$$a10.1021/la034197v
000081101 02470 $$2DAR$$a3915
000081101 02470 $$2ISI$$a000183994400004
000081101 037__ $$aARTICLE
000081101 245__ $$aHighly electrically insulating tethered lipid bilayers for probing the function of Ion channel proteins
000081101 269__ $$a2003
000081101 260__ $$c2003
000081101 336__ $$aJournal Articles
000081101 520__ $$aA method is presented to form gold-electrode-tethered lipid bilayers with exceptionally high elec. resistances. Elec. impedance spectroscopy is used to monitor the bilayer incorporation of a ligand-gated ion channel protein and the modulation of its channel activity by the selective binding of an antibody. Due to the low defect d. of the tethered membrane, the effect of a few channels can be resolved thus opening the way to single-channel expts. on this highly stable and versatile platform. In turn, a minute quantity of analyte, here antibodies, can be measured, which is of great interest for bioanalytics. [on SciFinder (R)]
000081101 700__ $$0241724$$aTerrettaz, Samuel$$g109839
000081101 700__ $$0241728$$aMayer, Michael$$g113417
000081101 700__ $$0240645$$aVogel, Horst$$g106666
000081101 773__ $$j19$$k14$$q5567-5569$$tLangmuir
000081101 909CO $$ooai:infoscience.tind.io:81101$$particle$$pSB
000081101 909C0 $$0252153$$pLCPPM$$xU10170
000081101 937__ $$aLCPPM-ARTICLE-2003-007
000081101 970__ $$a132/LCPPM
000081101 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000081101 980__ $$aARTICLE