Infoscience

Patent

Covalently immobilized phospholipid bilayers on solid surfaces

A solid coated device is disclosed that has covalently attached a coating which comprises a first layer contg. first functional groups, to which first layer functional groups is covalently attached a second, linking layer carrying second functional groups, to which second, linking layer is covalently attached a third, proximal phospholipid layer, to which third, proximal phospholipid layer is noncovalently attached a fourth, distal lipid layer, so that the proximal and the distal lipid layers together form a bilayer, into which lipid bilayer are optionally inserted receptor mols. A method for prepn. of the bilayers and uses thereof as biosensors or implantation devices also are disclosed. [on SciFinder (R)]

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