Control of yeast fed-batch process through regulation of extracellular ethanol concentration

At high growth rates, the biomass yield of baker's yeast (Saccharomyces cerevisiae) decreases due to the prodn. of ethanol. For this reason, it is std. industrial practice to use a fed-batch process whereby the specific growth rate, m, is fixed at a level below the point of ethanol prodn., i.e., mcrit. Optimally, growth should be maintained at mcrit, but in practice, this is difficult because mcrit is dependent upon strain and culture conditions. In this work, growth was maintained at a point just above mcrit by regulating ethanol concn. in the bioreactor. The models used for control design are shown, as are the exptl. results obtained when this strategy was implemented. This technique should be applicable to all microorganisms that exhibit an \"overflow\" type metab. [on SciFinder (R)]


Published in:
Bioprocess and Biosystems Engineering, 26, 6, 377-383
Year:
2004
Other identifiers:
Laboratories:




 Record created 2006-02-27, last modified 2018-03-17


Rate this document:

Rate this document:
1
2
3
 
(Not yet reviewed)