000080810 001__ 80810
000080810 005__ 20180317094902.0
000080810 0247_ $$2doi$$a10.1080/02652040210140490
000080810 02470 $$2ISI$$a000178639900003
000080810 037__ $$aARTICLE
000080810 245__ $$aQuantitative study of the production and properties of alginate/poly-L-lysine microcapsules
000080810 260__ $$c2002
000080810 269__ $$a2002
000080810 336__ $$aJournal Articles
000080810 520__ $$aAlginate-polylysine-alginate (APA) microcapsules are of particular interest for their application as implants or for bioreactor cultures. Although their formation has been widely studied, there is still a lack of quant. data describing resistance, membrance thickness and permeability. In this study, the quant. application of a Texture Analyzer for the measurement of capsule deformation yielded important results that permit comparison with other polymer systems used for encapsulation. Furthermore, single-membrane and multi-membrane capsules were formed in order to improve the modulation of the capsule properties. For single-membrane capsules, resistance was mostly affected by the incubation time in poly-L-lysine (PLL), the PLL mol. wt. and concn. The increase in resistance from 0.1+-0.01 g/capsules to 2+-0.2 g/capsules was linked to a membrane thickening (35-120 mm) and a decrease in permeability (150 to 40 kDa). Thus, it was not possible to modify resistance and membrane permeability independently. Multi-membrane capsules with a resistance comparable to single-membrane capsules could be formed using various combinations of PLL mol. wts., and enabled uncoupling of permeability and resistance properties. [on SciFinder (R)]
000080810 700__ $$0241551$$aGugerli, R.$$g101776
000080810 700__ $$aCantana, E.
000080810 700__ $$aHeinzen, C.
000080810 700__ $$0240951$$aVon Stockar, U.$$g106679
000080810 700__ $$0241101$$aMarison, I. W.$$g105760
000080810 773__ $$j19$$k5$$q571-590$$tJournal of Microencapsulation
000080810 909CO $$ooai:infoscience.tind.io:80810$$particle
000080810 909C0 $$0252160$$pLGCB$$xU10179
000080810 937__ $$aLGCB-ARTICLE-2002-007
000080810 970__ $$a185/LGCB
000080810 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000080810 980__ $$aARTICLE