A novel one-dimensional NOE expt. is presented where a selected proton is excited by two-way heteronuclear cross-polarization between protons and nitrogen-15 or carbon-13. The utility of the method is demonstrated for a sample of 15N labeled human ubiquitin. Inter- and intra-residue NOEs are clearly obsd. in a very time-effective manner. The signal intensities can be easily normalized. [on SciFinder (R)]