Difficulties are described which are encountered in NMR spectroscopy when attempting to invert simultaneously several multiplets that comprise transitions which share common energy levels. These problems turn out to be due to the undesirable excitation of multiple-quantum coherences. The discussion of these effects is limited to inversion with 2 simultaneous 180 Deg pulses having time-domain envelopes given either by simple rectangular box functions or by so-called G3 Gaussian pulse cascades. [on SciFinder (R)]