New synthetic route toward polyketide-like macrolides

New pathways toward the synthesis of polyketide-like macrolides have been developed through the functionalization of long chain polyolic fragments readily obtained from 3,3'-methylenebis{[6-(benzyloxy)methoxy]cyclohept-3-en-1-ol} derivatives 6. This synthetic route generates a large variety of stereoisomers and thus can be applied to the preparation of a library of polyhydroxylated macrocycles, analogues of natural bioactive macrolides.


Published in:
Synlett, 5, 685-688
Year:
2006
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 Record created 2006-02-16, last modified 2018-03-17


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