Pseudo-prolines (Psi Pro): direct insertion of Psi Pro systems into cysteine containing peptides
Guichou, JF; Patiny, L; Mutter, M
2002

Abstract

The direct conversion of cysteine (Cys) containing peptides into conformationally constrained pseudo-proline (TPro) derivatives by intraresidual N,S-acetalisation has been achieved. This post-synthetic modification represents a versatile tool in structure-activity studies of bioactive peptides as exemplified for the immunosuppressive cyclosporine A (CsA) analogue [D-Cys]*CsA. (C) 2002 Elsevier Science Ltd. All rights reserved.

Details

Title Pseudo-prolines (Psi Pro): direct insertion of Psi Pro systems into cysteine containing peptides
Author(s) Guichou, JF ; Patiny, L ; Mutter, M
Published in Tetrahedron Letters
Volume 43
Issue 24
Pages 4389-4390
Date 2002
ISSN 0040-4039
DOI https://doi.org/10.1016/S0040-4039(02)00755-4
Other identifier(s) DAR: 149
View record in Web of Science
Laboratories LCBP
Record Appears in Scientific production and competences > SB - School of Basic Sciences > SB Archives > LCBP - Laboratory of biomimetic and peptide chemistry
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Record creation date 2006-02-09

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