Targeting molecular recognition: exploring the dual role of functional pseudoprolines in the design of SH3 ligands
Tuchscherer, Gabriele; Grell, Daniel; Tatsu, Yoshiro; Durieux, Patricia; Fernandez-Carneado, Jimena; Hengst, Beatrice; Kardinal, Christian; Feller, Stephan
2001

Abstract

Pseudoproline-contg. peptide MeCO-Pro-Pro-Pro-Xaa-Pro-Val-Xaa-Pro-Pro-Pro-Pro-OH [Xaa = Ser(yProPh,H) = 2(S)-phenyloxazolidinyl-4-carboxylate] was synthesized and its conformation was examd. by CD spectroscopy. Its inhibition of the Grb2-SH3 domain was tested. [on SciFinder (R)]

Details

Title Targeting molecular recognition: exploring the dual role of functional pseudoprolines in the design of SH3 ligands
Author(s) Tuchscherer, Gabriele ; Grell, Daniel ; Tatsu, Yoshiro ; Durieux, Patricia ; Fernandez-Carneado, Jimena ; Hengst, Beatrice ; Kardinal, Christian ; Feller, Stephan
Published in Angewandte Chemie, International Edition
Volume 40
Issue 15
Pages 2844-2848
Date 2001
DOI https://doi.org/10.1002/1521-3773(20010803)40:15<2844::AID-ANIE2844>3.0.CO;2-F
Laboratories LCBP
Record Appears in Scientific production and competences > SB - School of Basic Sciences > SB Archives > LCBP - Laboratory of biomimetic and peptide chemistry
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Record creation date 2006-02-09

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