Synthetic routes to NEtXaa(4)-cyclosporin A derivatives as potential anti-HIV I drugs

An efficient synthesis in 10 steps and overall yields up to 27% of NEtXaa(4)-cyclosporin A derivatives (Xaa = Leu, Val, Ile, Thr) starting from cyclosporin A is described. Biological activities of the new analogues show promising results for the design of cyclosporin derivatives exhibiting non-immunosuppressive and anti-HIV activity. (C) 2000 Elsevier Science Ltd. All rights reserved.


Published in:
Tetrahedron Lett., 41, 37, 7193-7196
Year:
2000
ISSN:
0040-4039
Laboratories:




 Record created 2006-02-09, last modified 2018-01-27


Rate this document:

Rate this document:
1
2
3
 
(Not yet reviewed)