Abstract
An efficient synthesis in 10 steps and overall yields up to 27% of NEtXaa(4)-cyclosporin A derivatives (Xaa = Leu, Val, Ile, Thr) starting from cyclosporin A is described. Biological activities of the new analogues show promising results for the design of cyclosporin derivatives exhibiting non-immunosuppressive and anti-HIV activity. (C) 2000 Elsevier Science Ltd. All rights reserved.
Details
Title
Synthetic routes to NEtXaa(4)-cyclosporin A derivatives as potential anti-HIV I drugs
Published in
Tetrahedron Letters
Volume
41
Issue
37
Pages
7193-7196
Date
2000
ISSN
0040-4039
Laboratories
LCBP
Record Appears in
Scientific production and competences > SB - School of Basic Sciences > SB Archives > LCBP - Laboratory of biomimetic and peptide chemistry
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Record creation date
2006-02-09