Engineering of zinc finger motifs to \"locked-in tertiary folds\"

A symposium report on the solid-phase prepn. of template cyclopeptide cyclo[Lys(R)-Pro-Gly-Cys-Asp-Arg-Lys-Lys(R)-Pro-Gly-Phe-Ala-Cys-Ala] (R = COCH2ONH2) and helical 18-mer peptide aldehyde R1-Phe-Ser-Arg-Ser-Asp-Glu-Leu-Thr-Arg-His-Ile-Arg-Ile-His-Thr-Gly-Lys(R1)Gly-OH (R1 = COCHO) and double oxime formation of the template with the peptide aldehyde as a zinc finger DNA binding protein mimic. The synthetic peptide construct retains some helical structure even in the absence of zinc, as shown by CD. [on SciFinder (R)]


Published in:
Peptides 1996, Proceedings of the European Peptide Symposium, 24th, Edinburgh, Sept. 8-13, 1996, 847-848
Year:
1998
Laboratories:




 Record created 2006-02-09, last modified 2018-01-27


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