Engineering of zinc finger motifs to "locked-in tertiary folds"
A symposium report on the solid-phase prepn. of template cyclopeptide cyclo[Lys(R)-Pro-Gly-Cys-Asp-Arg-Lys-Lys(R)-Pro-Gly-Phe-Ala-Cys-Ala] (R = COCH2ONH2) and helical 18-mer peptide aldehyde R1-Phe-Ser-Arg-Ser-Asp-Glu-Leu-Thr-Arg-His-Ile-Arg-Ile-His-Thr-Gly-Lys(R1)Gly-OH (R1 = COCHO) and double oxime formation of the template with the peptide aldehyde as a zinc finger DNA binding protein mimic. The synthetic peptide construct retains some helical structure even in the absence of zinc, as shown by CD. [on SciFinder (R)]
Record created on 2006-02-09, modified on 2016-08-08