Protein mimetics (TASP) by sequential condensation of peptide loops to an immobilised topological template

The sequential condensation of peptide loops onto selectively addressable templates immobilised on solid supports allows the rapid and efficient synthesis of protein mimetics applying the TASP (Template Assembled Synthetic Protein) concept. As an example of the versatility of this methodology, we describe here the solid phase assembly of a representative 3-loop receptor mimetic. (C) 1997 Elsevier Science Ltd.


Published in:
Tetrahedron, 53, 21, 7231-7236
Year:
1997
ISSN:
0040-4020
Laboratories:




 Record created 2006-02-09, last modified 2018-01-27


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