Protein mimetics (TASP) by sequential condensation of peptide loops to an immobilised topological template
The sequential condensation of peptide loops onto selectively addressable templates immobilised on solid supports allows the rapid and efficient synthesis of protein mimetics applying the TASP (Template Assembled Synthetic Protein) concept. As an example of the versatility of this methodology, we describe here the solid phase assembly of a representative 3-loop receptor mimetic. (C) 1997 Elsevier Science Ltd.
Record created on 2006-02-09, modified on 2016-08-08