PSEUDO-PROLINES IN PEPTIDE-SYNTHESIS - DIRECT INSERTION OF SERINE AND THREONINE DERIVED OXAZOLIDINES IN DIPEPTIDES

Dipeptides containing serine and threonine derived oxazolidines are prepared by reacting side chain unprotected dipeptides containing C-terminal Thr or Ser with dimethoxypropane. The resulting building blocks can be coupled in Fmoc-based solid phase peptide synthesis enhancing peptide solvation by its secondary structure disrupting potential. The present procedure may be considered as a first step towards a reversible modification of structural and functional properties of bioactive peptides and proteins.


Published in:
Tetrahedron Lett., 36, 22, 3847-3848
Year:
1995
ISSN:
0040-4039
Laboratories:




 Record created 2006-02-09, last modified 2018-01-27


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