Infoscience

Journal article

SERINE DERIVED OXAZOLIDINES AS SECONDARY STRUCTURE DISRUPTING, SOLUBILIZING BUILDING-BLOCKS IN PEPTIDE-SYNTHESIS

The incorporation of serine as oxazolidine protected ''pseudo proline'' in a host peptide results in the disruption of secondary structure formation thus increasing the solvation of the peptide chain. The use of this protection technique for serine, threonine or cysteine represents a powerful tool to modulate the conformational and physico- chemical properties of peptides.

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