SWITCH PEPTIDES - PH-INDUCED ALPHA-HELIX TO BETA-SHEET TRANSITIONS OF BIS-AMPHIPHILIC OLIGOPEPTIDES
The interconversion of two secondary structure types (alpha-helix reversible beta-sheet) induced by external conditions such as pH, temperature, concentration, and solvent could be proved in a new class of amphiphilic peptides (switch peptides) in aqueous solution. The pH-dependent conformational changes were studied by CD spectroscopy. Special attention was given to the investigations of four newly synthesized peptides with similar sequences.
Record created on 2006-02-09, modified on 2016-08-08