SWITCH PEPTIDES - PH-INDUCED ALPHA-HELIX TO BETA-SHEET TRANSITIONS OF BIS-AMPHIPHILIC OLIGOPEPTIDES

The interconversion of two secondary structure types (alpha-helix reversible beta-sheet) induced by external conditions such as pH, temperature, concentration, and solvent could be proved in a new class of amphiphilic peptides (switch peptides) in aqueous solution. The pH-dependent conformational changes were studied by CD spectroscopy. Special attention was given to the investigations of four newly synthesized peptides with similar sequences.


Published in:
Angewandte Chemie, International Edition, 30, 11, 1514-1516
Year:
1991
ISSN:
1433-7851
Laboratories:




 Record created 2006-02-09, last modified 2018-01-27


Rate this document:

Rate this document:
1
2
3
 
(Not yet reviewed)