Deracemization of 5-(4-hydroxyphenyl)-5-phenylhydantoin (HPPH): practical synthesis of (-)-(S)-HPPH

In the presence of 10% NaOH in boiling MeOH enantiomerically enriched HPPH is racemized. This permits the deracemization of HPPH in the presence of brucine, giving enantiomerically pure (-)-(S)-HPPH [(-)-(S)-5-(4-hydroxyphenyl)-5-phenylhydandoin]. (C) 2004 Elsevier Ltd. All rights reserved.


Published in:
Tetrahedron-Asymmetry, 15, 17, 2657-2660
Year:
2004
ISSN:
0957-4166
Keywords:
Note:
Swiss Fed Inst Technol, Lab Glycochim & Synth Asymet, CH-1015 Lausanne, Switzerland.
Other identifiers:
Laboratories:




 Record created 2005-11-09, last modified 2018-03-17


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