New leads for selective inhibitors of alpha-L-fucosidases. Synthesis and glycosidase inhibitory activities of [(2R,3S,4R)-3,4-dihydroxypyrrolidin-2-yl]furan derivatives
2001
Abstract
Readily derived from D-glucose, 5-[(2R,3S,4R)-3,4-dihydroxypyrrolidin-2-yl]-2-methyl-3-furoic esters and amides are selective and competitive inhibitors (K(i)greater than or equal to3 muM) Of alpha -L-fucosidase from bovine epididymis and from human placenta. (C) 2001 Elsevier Science Ltd. All rights reserved.
Details
Title
New leads for selective inhibitors of alpha-L-fucosidases. Synthesis and glycosidase inhibitory activities of [(2R,3S,4R)-3,4-dihydroxypyrrolidin-2-yl]furan derivatives
Author(s)
Robina, I. ; Moreno-Vargas, A. J. ; Fernandez-Bolanos, J. G. ; Fuentes, J. ; Demange, R. ; Vogel, P.
Published in
Bioorganic & Medicinal Chemistry Letters
Volume
11
Issue
18
Pages
2555-2559
Date
2001
ISSN
0960-894X
Keywords
Note
Univ Sevilla, Fac Quim, Dept Quim Organ, E-41071 Seville, Spain. Univ Lausanne, Chim Sect, BCH, CH-1015 Lausanne, Switzerland.
Laboratories
LGSA
Record Appears in
Scientific production and competences > SB - School of Basic Sciences > SB Archives > LGSA - Laboratory of Glycochemistry and Asymmetric Synthesis
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Record creation date
2005-11-09