New leads for selective inhibitors of alpha-L-fucosidases. Synthesis and glycosidase inhibitory activities of [(2R,3S,4R)-3,4-dihydroxypyrrolidin-2-yl]furan derivatives

Readily derived from D-glucose, 5-[(2R,3S,4R)-3,4-dihydroxypyrrolidin-2-yl]-2-methyl-3-furoic esters and amides are selective and competitive inhibitors (K(i)greater than or equal to3 muM) Of alpha -L-fucosidase from bovine epididymis and from human placenta. (C) 2001 Elsevier Science Ltd. All rights reserved.


Published in:
Bioorganic & Medicinal Chemistry Letters, 11, 18, 2555-2559
Year:
2001
ISSN:
0960-894X
Keywords:
Note:
Univ Sevilla, Fac Quim, Dept Quim Organ, E-41071 Seville, Spain. Univ Lausanne, Chim Sect, BCH, CH-1015 Lausanne, Switzerland.
Laboratories:




 Record created 2005-11-09, last modified 2018-03-17


Rate this document:

Rate this document:
1
2
3
 
(Not yet reviewed)