Specific, uncompetitive inhibition of beta-galactosidases by a 5,6-isopropylidenedioxyfuro[2,3-d]isoxazole-3-methanol derivative
Schaller, C.; Demange, R.; Picasso, S.; Vogel, P.
1999

Abstract

(-)-(3aS,5S,6S,6aR)-3a,5,6,6a-Tetrahydro-5, 6-isopropylidenedioxyfuro[2,3-d]isoxazole-3-methanol ((-)-5) has been tested toward 25 glycohydrolases and found to inhibit beta-galactosidase from Aspergillus niger (K-i = 18 mu M) and that from Aspergillus orizae (K-i = 72 mu M) Hydrolysis of the acetonide or exchange of CH2OH group for a CHO, CH2OMe or a CH2OMOM group suppresses the inhibitory activity. (C) 1999 Elsevier Science Ltd. All rights reserved.

Details

Title Specific, uncompetitive inhibition of beta-galactosidases by a 5,6-isopropylidenedioxyfuro[2,3-d]isoxazole-3-methanol derivative
Author(s) Schaller, C. ; Demange, R. ; Picasso, S. ; Vogel, P.
Published in Bioorganic & Medicinal Chemistry Letters
Volume 9
Issue 2
Pages 277-278
Date 1999
ISSN 0960-894X
Keywords
Note Univ Lausanne, Inst Chim Organ, BCH, CH-1015 Lausanne, Switzerland.
DOI https://doi.org/10.1016/S0960-894X(98)00722-7
Laboratories LGSA
Record Appears in Scientific production and competences > SB - School of Basic Sciences > SB Archives > LGSA - Laboratory of Glycochemistry and Asymmetric Synthesis
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Record creation date 2005-11-09