Resolution of 7-oxabicyclo[2.2.1]hept-5-en-2-one via cyclic aminals
High yielding resolution of racemic 7-oxabicyclo[2.2.1]hept-5-en-2-one (+/-)-1 ('7-oxanorbornenone') via aminal formation with (R,R)-1,2-diphenylethylenediamine 2 is reported. Ac idle hydrolysis furnishes the enantiomeric ketones (+)-1 and (-)-1 (greater than or equal to 95% ee). The chiral diamine is efficiently recovered. (C) 1999 Elsevier Science Ltd. All rights reserved.
Univ Fribourg, Inst Chim Organ, CH-1700 Fribourg, Switzerland. Univ Lausanne, Inst Chim Organ, CH-1015 Lausanne, Switzerland.
Record created on 2005-11-09, modified on 2016-08-08