Carbaxylosides of 4-ethyl-2-oxo-2H-benzopyran-7-yl as non-hydrolyzable, orally active venous antithrombotic agents
Jeanneret, V.; Vogel, P.; Renaut, P.; Millet, J.; Theveniaux, J.; Barberousse, V.
1998

Abstract

A (-)-conduritol F derivative was condensed with 4-ethyl-7-hydroxy-2H-1-benzopyran-2-one and converted into (+)-4-ethyl-7-[( 1'R,2'S,3'S,4'R)-2',3',4'-trihydroxycyclohexyloxy]-2H-1benzopyran-2-one ((+)-2) Enantiomer (-)-2 was obtained from a (+)-conduritol F derivative. The carbaxyloside (-)-2 with the L-xylose configuration was more active than (+)-2 in the Wessler's model. (C) 1998 Elsevier Science Ltd. All rights reserved.

Details

Title Carbaxylosides of 4-ethyl-2-oxo-2H-benzopyran-7-yl as non-hydrolyzable, orally active venous antithrombotic agents
Author(s) Jeanneret, V. ; Vogel, P. ; Renaut, P. ; Millet, J. ; Theveniaux, J. ; Barberousse, V.
Published in Bioorganic & Medicinal Chemistry Letters
Volume 8
Issue 13
Pages 1687-1688
Date 1998
ISSN 0960-894X
Keywords
Note Univ Lausanne, Inst Chim Organ, BCH, CH-1015 Lausanne, Switzerland. Labs Fournier SA, Ctr Rech, F-21121 Daix, France.
DOI https://doi.org/10.1016/S0960-894X(98)00283-2
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