Journal article

Carbaxylosides of 4-ethyl-2-oxo-2H-benzopyran-7-yl as non-hydrolyzable, orally active venous antithrombotic agents

A (-)-conduritol F derivative was condensed with 4-ethyl-7-hydroxy-2H-1-benzopyran-2-one and converted into (+)-4-ethyl-7-[( 1'R,2'S,3'S,4'R)-2',3',4'-trihydroxycyclohexyloxy]-2H-1benzopyran-2-one ((+)-2) Enantiomer (-)-2 was obtained from a (+)-conduritol F derivative. The carbaxyloside (-)-2 with the L-xylose configuration was more active than (+)-2 in the Wessler's model. (C) 1998 Elsevier Science Ltd. All rights reserved.


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