Carbaxylosides of 4-ethyl-2-oxo-2H-benzopyran-7-yl as non-hydrolyzable, orally active venous antithrombotic agents

A (-)-conduritol F derivative was condensed with 4-ethyl-7-hydroxy-2H-1-benzopyran-2-one and converted into (+)-4-ethyl-7-[( 1'R,2'S,3'S,4'R)-2',3',4'-trihydroxycyclohexyloxy]-2H-1benzopyran-2-one ((+)-2) Enantiomer (-)-2 was obtained from a (+)-conduritol F derivative. The carbaxyloside (-)-2 with the L-xylose configuration was more active than (+)-2 in the Wessler's model. (C) 1998 Elsevier Science Ltd. All rights reserved.


Published in:
Bioorganic & Medicinal Chemistry Letters, 8, 13, 1687-1688
Year:
1998
ISSN:
0960-894X
Keywords:
Note:
Univ Lausanne, Inst Chim Organ, BCH, CH-1015 Lausanne, Switzerland. Labs Fournier SA, Ctr Rech, F-21121 Daix, France.
Laboratories:




 Record created 2005-11-09, last modified 2018-03-17


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