Dihydroxypyrrolidines C-linked to galactose. Total synthesis of a specific inhibitor of alpha-mannosidases

New disaccharide mimics connecting 4-amino-4-deoxyerythrofuranose at C(1) to position C(3) of galactose through a CH(OH) link have been prepared as racemates and tested toward 25 commercially available glycohydrolases. One of them (2) is a moderate but specific (43% of inhibition at 1 mM) inhibitor of jack bean alpha-mannosidase. (C) 1997 Elsevier Science Ltd.


Published in:
Bioorganic & Medicinal Chemistry Letters, 7, 7, 893-896
Year:
1997
ISSN:
0960-894X
Keywords:
Note:
Univ lausanne,chim sect,bch,ch-1015 lausanne,switzerland.
Laboratories:




 Record created 2005-11-09, last modified 2018-03-17


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