Dihydroxypyrrolidines C-linked to galactose. Total synthesis of a specific inhibitor of alpha-mannosidases
Kraehenbuehl, K.; Picasso, S.; Vogel, P.
1997

Abstract

New disaccharide mimics connecting 4-amino-4-deoxyerythrofuranose at C(1) to position C(3) of galactose through a CH(OH) link have been prepared as racemates and tested toward 25 commercially available glycohydrolases. One of them (2) is a moderate but specific (43% of inhibition at 1 mM) inhibitor of jack bean alpha-mannosidase. (C) 1997 Elsevier Science Ltd.

Details

Title Dihydroxypyrrolidines C-linked to galactose. Total synthesis of a specific inhibitor of alpha-mannosidases
Author(s) Kraehenbuehl, K. ; Picasso, S. ; Vogel, P.
Published in Bioorganic & Medicinal Chemistry Letters
Volume 7
Issue 7
Pages 893-896
Date 1997
ISSN 0960-894X
Keywords
Note Univ lausanne,chim sect,bch,ch-1015 lausanne,switzerland.
DOI https://doi.org/10.1016/S0960-894X(97)00135-2
Laboratories LGSA
Record Appears in Scientific production and competences > SB - School of Basic Sciences > SB Archives > LGSA - Laboratory of Glycochemistry and Asymmetric Synthesis
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Record creation date 2005-11-09