Abstract

The "naked sugar" (+)-(1R,2R,4R)-2-cyano-7-oxabicyclo[2.2.1]hept-5-en-2-exo-yl acetate ((+)-3) was converted in ten synthetic steps into the new C-nucleoside (1R)-1-C-(6'-amino-7'H-purin-8'-yl)-1,4-anhydro-3-azido-2,3-dideoxy-D-er ythro-pentitol ((+)-2) in 19% overall yield.

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