An expeditious asymmetric synthesis of polyfunctional 1,7-dioxaspiro[5.5]undecanes

Quick access to polyfunctional spiroketal (3R)-4-[(2S,6R,8R, 10S)-4,4-bis(ethylthio)-10-hydroxy-8-(2-hydroxyethyl)- 1,7-dioxaspiro[5.5]undec-2-yl]butane- 1,3-diol [(+)-19] is now available through the stereoselective functionalization of enantiomerically pure protected tetrol (4R,4'R,6R,6'R)- 1, l'-methylenebis[4-[(benzyloxy)methoxy]-6-[(triethylsilyl)-oxy]cyclohept- 1-ene [(-)-9], derived from 2,2'-methylenedifuran. (C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004).


Published in:
European Journal of Organic Chemistry, 24, 5040-5046
Year:
2004
ISSN:
1434-193X
Keywords:
Laboratories:




 Record created 2005-11-09, last modified 2018-03-17


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