Total asymmetric synthesis of a new 9,12-anhydroerythronolide aglycone

Two novel, potentially antimicrobial erythronolide aglycon analogs ((-)-9 and (-)-30, respectively), which incorporate a large number of contiguous stereogenic centers, have been prepared by multistep synthesis from simple chirons. The chemistry presented demonstrates the power of the so-called 'naked sugars of the second acneration' approach. As for the sporeamicins, our macrolides are 9,12-anhydroerythronotides, yet presenting a higher degree of complexity due to additional functional groups.


Published in:
Helv. Chim. Acta, 85, 2, 417-430
Year:
2002
ISSN:
0018-019X
Keywords:
Other identifiers:
Laboratories:




 Record created 2005-11-09, last modified 2018-03-17


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