Total synthesis of the C-37-C-45 F-ring fragment of spongistatins

The highly substituted F ring of Spongistatins was synthesized from (R)-(+)-3-benzyloxy-2-methylpropan-1-ol (5), using two sequential Sharpless dihydroxylations as key-steps. A 4-deoxy-4-methyl-D-threo-L-glucoheptopyranose derivative was obtained and could be used to generate the corresponding allyl beta-C-glycoside. (C) 1998 Elsevier Science Ltd. All rights reserved.


Published in:
Tetrahedron Lett., 39, 11, 1345-1348
Year:
1998
ISSN:
0040-4039
Keywords:
Laboratories:




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