Methodology description for detection of cellular uptake of PVA coated superparamagnetic iron oxide nanoparticles (SPION) in synovial cells of sheep
The detection of superparamagnetic iron oxide nanoparticles (SPION) in synoviocytes is reported. Synoviocytes were incubated for 2, 12, 24 and 48 h with 1.5 mg/ml of PVA coated SPION under the influence of magnets (12 h). Particles were well tolerated by the synoviocytes, were easily detected using the Turnbulls and Prussian blue reactions between 12 and 24 h.
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Keywords: Nanoparticles ; Iron oxide ; Magnetic drug targeting ; Synoviocytes cell culture ; Polyvinyl alcohol (PVA) coating ; SPION ; Iron detection ; Histology ; Pearl's Prussian blue ; Turnbulls reaction ; Toxicity ; Biocompatibility
Record created on 2005-04-01, modified on 2016-08-08