A study of prompt Ξ+c production in proton-lead collisions is performed with the LHCb experiment at a centre-of-mass energy per nucleon pair of 8.16 TeV in 2016 in pPb and Pbp collisions with an estimated integrated luminosity of approximately 12.5 and 17.4 nb−1, respectively. The Ξ+c production cross-section, as well as the Ξ+c to Λ+c production cross-section ratio, are measured as a function of the transverse momentum and rapidity and compared to latest theory predictions. The forward-backward asymmetry is also measured as a function of the Ξ+c transverse momentum.