The plasma design point during stationary phase operation of EU-DEMO has been described extensively in the past, and the assumptions employed for its definition have been supported by various investigations. However, a stationary snapshot is by far not sufficient to ensure the actual operability of the plasma scenario. On the con-trary, both normal and off-normal transients have a strong impact on the machine design, providing the most challenging requirements to the actuators. This has to be accounted for in the design from the early phases on. In this paper, the main requirements originating from plasma operation, studied during the Pre-Concept Design Phase, are briefly reviewed. These encompass the so-called planned transients, e.g. plasma current ramps, access and termination of the burn phase or plasma fueling with pellets, but also the mitigation of off-normal events which may lead to a disruption, e.g. the divertor reattachment or an uncontrolled increase of radiation after a sudden W influx from the wall.