Hot exciton materials have the potential to improve the quantum efficiency of organic light-emitting diodes (OLEDs) by promoting high reversed intersystem crossing (hRISC) between a high-lying triplet (T-n, n >= 2) and a radiative singlet (S-m). In recent years, donor-acceptor-donor (D-A-D) molecular systems have shown great promise in its ability to enhance the hRISC process under certain conditions. However, strategies to find appropriate D-A-D combinations beyond trial-and-error are still elusive. This work exposes the limited applicability of the current fragment-based design rules and proposes high-throughput screening as the optimal route to find candidates that fulfill the energy criteria for hRISC. The strategy consists of first establishing the thresholds for large triplet-triplet splitting and small singlet-triplet gap, then filtering combinations through rate comparison of competitive crossing pathways, and finally confirming hRISC with spin-orbital coupling evaluation. Based on a dataset of 234 compounds, this protocol identifies 31 candidates with potential for hRISC, 4 of which are reported in the literature. Remarkably, while most of the promising systems show prominent hybridized local and charge transfer character, several candidates do not fulfill this condition, indicating that different routes are possible to design efficient OLED materials.