In extension with growing concern to develop new antimicrobial organometallic drugs, an attempt has been made to synthesize five new antimicrobial organotin(IV) carbodithioates with general formula, Me2SnClL (1), Me2SnL2 (2), Et2SnClL (3), Et2SnL2 (4), Bu2SnClL (5), Bu2SnL2 (6), (where L = Sodium 3,4-dihydroisoquinoline-2-(1H)-carbodithioate). Compounds have been synthesized by refluxing organotin(IV) chlorides with ligand in dry toluene for 7-8 h. Compound 1, 3 and 5 exhibited Penta coordination, while 2, 4 and 6 showed hexacoordination in solid state, as evident from the difference obtained between symmetric and asymmetric CSS stretches in IR spectra. Solid-state structures of 1 was further attested by single crystal analysis as distorted trigonal bipyramidal geometry. H-1-, C-13- and Sn-119- NMR spectroscopy was used to assess the geometry of the compounds in solution state. It was observed that 1, 3, 4 and 5 completely dissociated in solution and showed tetrahedral geometry, whereas 2 and 6 exhibit pentacoordinate geometry after partial dissociation in solution. The pronounced activity was observed for all the compounds against five different strains of bacteria. (C) 2021 Elsevier B.V. All rights reserved.