The opening of the Guggenheim Museum in Bilbao in 1997 heralded the beginning of an era in world architecture defined by iconic buildings underpinned by mediatic exposure and the belief in the power of design to leverage urban conditions. Today, a conspicuous number of such buildings featuring non-standard geometries are experiencing accelerated forms of decay with the emergence of construction defects. This study compares the type of problems encountered in the Jubilee Church in Rome (1996–2003), analysed in previous studies, with the failures of other two contemporary buildings of analogous features, namely: the Palau de les Arts Reina Sofia in Valencia (1996–2005) and the Museum of the Arts of the XXI Century in Rome (1998–2010). The findings of the study show that the accelerated decay of the three buildings shares familiar features and common challenges: geometry of the façade, local environmental factors, labour organisation, and limited regard of maintenance principles. Building on the patterns identified here, the paper suggests structural reasons for their emergence and speculates on the potential benefits deriving from the amplification of the design function.