Recent works have established bio-based carboxylic acids as adaptable precursors to renewable biofuels and chemicals. However, the separation of carboxylic acids is a major energy and cost driver, accounting for 20-40% of the entire processing cost. Improved downstream separation technologies that reduce operating costs compared to conventional approaches are needed, particularly to enable bio-based commodity fuels and chemicals. Here, we combine techno-economic analysis (TEA) and an energy and environmental assessment with experimental results to compare weak-base adsorption (WBA) processes with the conventional strong ion exchange (IX) process for the recovery of the exemplary product, butyric acid. TEA indicates that WBA has the potential to reduce operating expenses from 34% to 6% relative to the selling price of butyric acid ($1.8 kg(-1)). Our energy analysis shows that the WBA process has 12.2-fold energy reduction and 9.2-fold GHG emission reduction compared to the conventional IX process.