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research article
Catalytic (3+2) annulation of donor-acceptor aminocyclopropane monoesters and indoles
May 5, 2021
The efficient catalytic activation of donor-acceptor aminocyclopropanes lacking the commonly used diester acceptor is reported here in a (3 + 2) dearomative annulation with indoles. Bench-stable tosyl-protected aminocyclopropyl esters were converted into cycloadducts in 46-95% yields and up to 95 : 5 diastereomeric ratio using catalytic amounts of triethylsilyl triflimide. Tricyclic indoline frameworks containing four stereogenic centers including all-carbon quaternary centers were obtained.
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Name
CS2021-8706GoldAccess.pdf
Type
Publisher's version
Access type
openaccess
License Condition
CC BY
Size
20.73 MB
Format
Adobe PDF
Checksum (MD5)
644fc2efb1308c0dd428aac15e7d9ae7