Three dimensional models of tissue fibrosis
Rezakhani, Saba; Yildiz, Ece; Schoonjans, Kristina; Lutolf, Matthias; Sorrentino, Giovanni
2020

Abstract

The invention provides a method for obtaining a three-dimensional (3D) cellular model of tissue fibrosis, such as liver fibrosis, comprising culturing epithelial cells in a 3D hydrogel in conditions suitable for a three-dimensional cellular cluster formation, wherein the hydrogel comprises a crosslinked hydrophilic polymer having a shear modulus of at least 4 kPa, such as between about 4 and about 10 kPa.

Details

Title Three dimensional models of tissue fibrosis
Author(s) Rezakhani, Saba ; Yildiz, Ece ; Schoonjans, Kristina ; Lutolf, Matthias ; Sorrentino, Giovanni
Date 2020
Keywords
Note Alternative title(s) : (fr) Modèles tridimensionnels de fibrose tissulaire
Other identifier(s) EPO Family ID: 66751895
Patent number(s) WO2020239990 (A1)
Laboratories TTO
UPLUT
UPSCHOONJANS
Record Appears in Scientific production and competences > SV - School of Life Sciences > IBI-SV - Interfaculty Institute of Bioengineering > UPLUT - Prof. Lutolf Group
Scientific production and competences > Non-academic units > TTO - Technology Transfer Office
Work produced at EPFL
Patents
Record creation date 2021-01-04

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