A Chiral Naphthyridine Diimine Ligand Enables Nickel‐Catalyzed Asymmetric Alkylidenecyclopropanations

A novel class of chiral naphthyridine diimine ligands (NDI*) readily accessible from C2‐symmetric 2,6‐di‐(1‐arylethyl)anilines is described. The utility of these ligands, particularly one with fluorinated aryl side arms, is demonstrated by a reductive Ni‐catalyzed enantioselective alkylidene transfer reaction from 1,1‐dichloroalkenes to olefins. This transformation provides direct access to a broad range of synthetically valuable alkylidenecyclopropanes in high yields and enantioselectivities.


Published in:
Angewandte Chemie International Edition, 59, 38, 16425-16429
Year:
Jun 10 2020
Keywords:
Laboratories:


Note: The file is under embargo until: 2020-12-10


 Record created 2020-10-12, last modified 2020-10-28

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