Palladium-Catalyzed Multicomponent Synthesis of Fully Substituted Alkylidene Furanones

In the presence of a catalytic amount of Pd(OAc)(2) and XantPhos, the three-component reaction of ynones, imines, and aryl iodides affords fully substituted alkylidene-furan-3(2H)-ones via a sequence of the Mannich reaction followed by chemo- and regioselective oxypalladation and reductive elimination. One carbon-oxygen and two carbon-carbon bonds are generated to afford the heterocycle in good to excellent yield.


Published in:
Organic Letters, 22, 17, 7030-7033
Year:
Sep 04 2020
Publisher:
Washington, AMER CHEMICAL SOC
ISSN:
1523-7060
1523-7052
Keywords:
Laboratories:




 Record created 2020-10-01, last modified 2020-10-15


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