The outstanding physico-chemical properties of carbon nanotubes (CNTs) applied to rectify the problems in bone tissue engineering through enhancing cell proliferation, adhesion and viability, which lead to the improvement in bone replacement, growth and healing. Hence, in this study, biocompatible polymers functionalized with CNTs and then synthetic bone minerals i.e. hydroxyapatite has been stabilized onto CNTs-polymer matrixes. Structural morphology of the materials was analyzed by spectroscopic/microscopic analyses. The cytotoxic property of nanohybrids was examined on osteoblast-like MG-63 cells. The lack of significant cytotoxic effect of nanohybrids suggested that the nanohybrids are considered as promising candidates for bone tissue engineering applications.