Anhydrous Conditions Enable the Catalyst-Free Carboxylation of Aromatic Alkynes with CO2 under Mild Conditions
Toniolo, Davide; Bobbink, Felix D.; Dyson, Paul J.; Mazzanti, Marinella
2020

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Abstract

The direct carboxylation of aromatic alkynes with CO2, a cheap and widely available C1 source, is the most attractive method for the synthesis of carboxylic acids. Here we show that direct carboxylation of terminal alkynes can be simply performed in near-quantitative yield in four hours with anhydrous Cs2CO3 under mild conditions without need of a metal catalyst.

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Title Anhydrous Conditions Enable the Catalyst-Free Carboxylation of Aromatic Alkynes with CO2 under Mild Conditions
Author(s) Toniolo, Davide ; Bobbink, Felix D. ; Dyson, Paul J. ; Mazzanti, Marinella
Published in Helvetica Chimica Acta
Volume 103
Issue 2
Pages e1900258
Date 2020-01-27
ISSN 0018-019X
1522-2675
Keywords
DOI https://doi.org/10.1002/hlca.201900258
Other identifier(s) View record in Web of Science
Laboratories LCOM
GCC
Record Appears in Scientific production and competences > SB - School of Basic Sciences > ISIC - Institute of Chemical Sciences and Engineering > LCOM - Laboratory of Organometallic and Medicinal Chemistry
Scientific production and competences > SB - School of Basic Sciences > ISIC - Institute of Chemical Sciences and Engineering > GCC - Group of Coordination Chemistry
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Record creation date 2020-03-03

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