Biotechnologies to tackle the challenge of neoantigen identification

Among immune correlates of clinical responses, tumor-specificneoantigens took the spotlight as relevant targets for cancerimmunotherapy. The implementation of pipelines forpersonalized cancer therapy remains challenging due to theprivacy, that is patient-specificity, of neoantigens and the low-frequency of neoantigen-specific T cells in blood and tumorsamples. To overcome these obstacles, recent developmentsin the field of biotechnology have allowed the multiplexedidentification of neoepitope-specific T cells. This reviewaddresses the pros and cons of conventional neoantigenscreening methodologies and highlights the current as well asthe prospective biotechnological opportunities in the field.


Published in:
Current Opinion in Biotechnology, 65, 52-59
Year:
Jan 08 2020
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Note: The status of this file is: EPFL only


 Record created 2020-02-07, last modified 2020-04-20

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