Is it feasible to directly access the bundle’s specific myelin content, instead of averaging? A study with Microstructure Informed Tractography

Diffusion MRI connectometry is a widely used tool to investigate features of structural connectomes that reflect differences in white matter tracks integrity. It consists in averaging microstructural tissues properties (obtained from any voxel-wise map) along streamlines recovered with diffusion tractography. Nevertheless, the average of a microstructural measure is a weak information about an entire bundle. Using microstructure-informed tractography (COMMIT), we were able to simultaneously estimate fiber’s specific myelin water fraction, intra-axonal volume fraction, and g-ratio. We also computed new connectomes with bundles’ specific measures instead of the commonly used averages.

Presented at:
ISMRM 27th Annual Meeting & Exhibition, Montréal, Canada, Mai 11-16, 2019

 Record created 2020-01-02, last modified 2020-10-25

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