Novel osmium(II)-cymene complexes containing curcumin and bisdemethoxycurcumin ligands

The first examples of (arene)Os(II) curcuminoid derivatives have been prepared and characterized. The neutral complexes [(p-cym)Os(curc)Cl] (1) and [( p-cym)Os(bdcurc)Cl] ( 2), together with the cationic derivatives [( p-cym)Os(curc)(PTA)][SO3CF3] (3) and [( p-cym)Os(bdcurc)(PTA)][SO3CF3] (4) (PTA = 1,3,5-triaza-7-phosphaadamantane) were characterized by NMR spectroscopy and ESI mass spectrometry, and the crystal structure of 1 was determined by X-ray diffraction analysis. The cytotoxicity of the complexes was evaluated in vitro against human ovarian carcinoma cells (A2780 and A2780cisR), as well as against non-tumorous Human Embryonic Kidney cells (HEK293). Binding of the complexes to potential pharmacological targets and serum carriers was also explored.


Published in:
Inorganic Chemistry Frontiers, 6, 9, 2448-2457
Year:
Sep 01 2019
Publisher:
Cambridge, ROYAL SOC CHEMISTRY
ISSN:
2052-1553
Keywords:
Laboratories:




 Record created 2019-11-05, last modified 2020-10-29


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