Synthesis of diphenoxyadamantane alkylamines with pharmacological interest

In this work, the synthesis and the pharmacological evaluation of diphenoxyadamantane alkylamines Ia-f and IIa-f is described. The new diphenoxy-substituted adamantanes share structural features present in trypanocidal and antitubercular agents. 1-Methylpiperazine derivative Ia is the most potent against T. brucei compound, whilst its hexylamine congener IIf exhibits a significant antimycobacterial activity.


Published in:
Bioorganic & Medicinal Chemistry Letters, 29, 11, 1278-1281
Year:
Jun 01 2019
Publisher:
Oxford, PERGAMON-ELSEVIER SCIENCE LTD
ISSN:
0960-894X
1464-3405
Keywords:
Laboratories:




 Record created 2019-06-18, last modified 2019-06-25


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