000266946 001__ 266946
000266946 005__ 20190626160005.0
000266946 022__ $$a0194-5998
000266946 022__ $$a1097-6817
000266946 02470 $$a000458211400012$$2isi
000266946 0247_ $$a10.1177/0194599818791779$$2doi
000266946 037__ $$aARTICLE
000266946 245__ $$aPrediction of Occult Lymph Node Metastasis in Head and Neck Cancer with CD31 Vessel Quantification
000266946 260__ $$c2019$$aLondon$$bSAGE PUBLICATIONS LTD
000266946 269__ $$a2019-02-01
000266946 336__ $$aJournal Articles
000266946 520__ $$aObjective The management of occult lymph node metastasis (LNM) in head and neck squamous cell carcinoma has been a matter of controversy for decades. The vascular density within the tumor microenvironment, as an indicator of ongoing angiogenesis, could constitute an attractive predictor of LNM. The use of the panvascular endothelial antibody CD31 as a marker of occult LNM has never been reported. The aim of this study was to assess the predictive value of CD31 microvascular density for the detection of occult LNM in squamous cell carcinoma of the oral cavity and oropharynx. Study Design Case series with chart review. Setting Tertiary university hospital. Subjects and Methods Intra- and peritumoral microvascular density values were determined in 56 cases of squamous cell carcinoma of the oral cavity (n = 50) and oropharynx (n = 6) with clinically negative necks using the CD31 marker. Statistical associations of CD31 microvascular densities with clinicopathologic data were then established. Results Peritumoral CD31 microvascular density was significantly associated with occult LNM in multivariate analysis (P < .01). Recursive partitioning analysis for this parameter found a cutoff of 19.33, which identified occult LNM with a sensitivity of 91%, a specificity of 65%, a positive predictive value of 40%, a negative predictive value of 97%, and an overall diagnostic accuracy of 71%. Conclusion Peritumoral CD31 microvascular density in primary squamous cell carcinoma of the oral cavity and oropharynx allows accurate prediction of occult LNM.
000266946 650__ $$aOtorhinolaryngology
000266946 650__ $$aSurgery
000266946 650__ $$aOtorhinolaryngology
000266946 650__ $$aSurgery
000266946 6531_ $$acd31
000266946 6531_ $$aoccult lymph node metastasis
000266946 6531_ $$ahead and neck squamous cell carcinoma
000266946 6531_ $$aprognosis
000266946 6531_ $$abiomarkers
000266946 6531_ $$asquamous-cell carcinoma
000266946 6531_ $$aoral-cavity
000266946 6531_ $$aprognostic-factors
000266946 6531_ $$atherapeutic neck
000266946 6531_ $$ainvasive front
000266946 6531_ $$astage-i
000266946 6531_ $$aangiogenesis
000266946 6531_ $$atumor
000266946 6531_ $$amalignancy
000266946 6531_ $$aexpression
000266946 700__ $$aMermod, Maxime
000266946 700__ $$aBongiovanni, Massimo
000266946 700__ $$aPetrova, Tatiana
000266946 700__ $$aGoun, Elena$$0246452$$g217627
000266946 700__ $$aSimon, Christian
000266946 700__ $$aTolstonog, Genrich
000266946 700__ $$aMonnier, Yan
000266946 773__ $$k2$$j160$$q277-283$$tOtolaryngology-Head And Neck Surgery
000266946 8560_ $$firina.lopez@epfl.ch
000266946 909C0 $$zBorel, Alain$$0252473$$yApproved$$pLCBIM$$xU12499$$mirina.lopez@epfl.ch
000266946 909CO $$particle$$ooai:infoscience.epfl.ch:266946$$pSB
000266946 961__ $$apierre.devaud@epfl.ch
000266946 973__ $$aEPFL$$sPUBLISHED$$rREVIEWED
000266946 980__ $$aARTICLE
000266946 980__ $$aWoS
000266946 981__ $$aoverwrite